Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease
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چکیده
منابع مشابه
Gender differences in NGF receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer’s disease
The higher incidence rate of Alzheimer’s disease (AD) in elderly women indicates that gender plays a role in AD pathogenesis. Evidence from clinical and pharmacologic studies, neuropathological examinations, and models of hormone replacement therapy suggest that cholinergic basal forebrain (CBF) cortical projection neurons within the nucleus basalis (NB), which mediate memory and attention and ...
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Time course of dysregulation of calcium homeostasis in acutely isolated CA1 hippocampal pyramidal neurons after pilocarpine-induced Status Epilepticus
Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...
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Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2016
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2016.02.031